Synthesis of analogs of forodesine HCl, a human purine nucleoside phosphorylase inhibitor-Part II

Vivekanand P Kamath; Jie Xue; Jesus J Juarez-Brambila

doi:10.1016/j.bmcl.2009.04.018

Synthesis of analogs of forodesine HCl, a human purine nucleoside phosphorylase inhibitor-Part II

Bioorg Med Chem Lett. 2009 May 15;19(10):2627-9. doi: 10.1016/j.bmcl.2009.04.018. Epub 2009 Apr 9.

Authors

Vivekanand P Kamath¹, Jie Xue, Jesus J Juarez-Brambila

Affiliation

¹ BioCryst Pharmaceuticals Inc., Birmingham, AL 35244, United States. vkamath@biocryst.com

PMID: 19386496
DOI: 10.1016/j.bmcl.2009.04.018

Abstract

Forodesine HCl is being investigated as a potential therapeutic target for the control of T-cell proliferation. During the filing process for a New Drug Application (NDA) it became evident that there was a need to synthesize some stereo-isomers of forodesine HCl. Herein we present the synthesis of these three novel compounds (2-4).

MeSH terms

Cell Proliferation
Enzyme Inhibitors / chemical synthesis*
Enzyme Inhibitors / chemistry
Enzyme Inhibitors / pharmacology
Humans
Purine Nucleosides / chemical synthesis*
Purine Nucleosides / chemistry
Purine Nucleosides / pharmacology
Purine-Nucleoside Phosphorylase / antagonists & inhibitors*
Purine-Nucleoside Phosphorylase / metabolism
Pyrimidinones / chemical synthesis*
Pyrimidinones / chemistry
Pyrimidinones / pharmacology
T-Lymphocytes / immunology
T-Lymphocytes / metabolism

Substances

Enzyme Inhibitors
Purine Nucleosides
Pyrimidinones
forodesine
Purine-Nucleoside Phosphorylase